Reactome | Phosphorylation of cohesin by PLK1 at chromosomal arms

Schema > Reaction > Entries

Phosphorylation of cohesin by PLK1 at chromosomal arms Show undefined attributes

catalystActivity	[CatalystActivity:10114580] protein serine/threonine kinase activity of p-T210-PLK1 [cytosol]
category	transition
compartment	[Compartment:1598585] chromosome [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10166862
displayName	Phosphorylation of cohesin by PLK1 at chromosomal arms
eventOf	[Pathway:R-RNO-2500257] Resolution of Sister Chromatid Cohesion - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2467794] Resolution of sister chromatids - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:18485] sister chromatid cohesion
inferredFrom	[Reaction:R-HSA-2466068] Phosphorylation of cohesin by PLK1 at chromosomal arms - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-2468274] Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of cohesin by PLK1 at chromosomal arms
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-1638805] Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome]
precedingEvent	[Reaction:R-RNO-2468293] CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms - Rattus norvegicus [Reaction:R-RNO-3000327] PLK1 phosphorylates BORA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2466068
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2500257] Resolution of Sister Chromatid Cohesion
(precedingEvent)	[Reaction:R-RNO-2467794] Resolution of sister chromatids
(inferredTo)	[Reaction:R-HSA-2466068] Phosphorylation of cohesin by PLK1 at chromosomal arms

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