Reactome | STRA6 transports atROL from extracellular region to cytosol

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STRA6 transports atROL from extracellular region to cytosol Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10166690
displayName	STRA6 transports atROL from extracellular region to cytosol
eventOf	[Pathway:R-RNO-2453902] The canonical retinoid cycle in rods (twilight vision) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-74843] atROL binds RBP1 to form RBP1:atROL - Rattus norvegicus [Reaction:R-RNO-5362518] RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL - Rattus norvegicus [Reaction:R-RNO-5362564] ADH1A,1C,4 oxidise atROL to atRAL in vitro - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2453863] STRA6 transports atROL from extracellular region to cytosol - Homo sapiens
input	[Complex:R-RNO-2453850] TTR:RBP4:atROL:STRA6 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	STRA6 transports atROL from extracellular region to cytosol All-trans-retinol is taken up by cells expressing STRA6 receptor
output	[SimpleEntity:R-ALL-2473604] atROL [cytosol] [Complex:R-RNO-2453860] TTR:RBP4:STRA6 [plasma membrane]
precedingEvent	[Reaction:R-RNO-2453876] TTR:RBP:atROL binds to STRA6 receptor - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2453863
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2453902] The canonical retinoid cycle in rods (twilight vision)
(precedingEvent)	[Reaction:R-RNO-74843] atROL binds RBP1 to form RBP1:atROL [Reaction:R-RNO-5362518] RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL [Reaction:R-RNO-5362564] ADH1A,1C,4 oxidise atROL to atRAL in vitro
(inferredTo)	[Reaction:R-HSA-2453863] STRA6 transports atROL from extracellular region to cytosol

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