Reactome | IGF1,2:IGF1R autophosphorylates

Schema > Reaction > Entries

IGF1,2:IGF1R autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10166412] protein tyrosine kinase activity of IGF1,2:IGF1R [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10166419
displayName	IGF1,2:IGF1R autophosphorylates
eventOf	[Pathway:R-RNO-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Rattus norvegicus [Reaction:R-RNO-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 - Rattus norvegicus [Reaction:R-RNO-2428930] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2404199] IGF1,2:IGF1R autophosphorylates - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-2404186] IGF1,2:IGF1R [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IGF1,2:IGF1R autophosphorylates
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-2404189] IGF1,2:p-3Y-IGF1R [plasma membrane]
precedingEvent	[Reaction:R-RNO-2404200] IGF1,2 binds IGF1R - Rattus norvegicus
regulatedBy	[NegativeRegulation:10166420] Negative regulation by 'glc-fuc-CILP [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2404199
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
(precedingEvent)	[Reaction:R-RNO-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 [Reaction:R-RNO-2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 [Reaction:R-RNO-2428930] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4
(inferredTo)	[Reaction:R-HSA-2404199] IGF1,2:IGF1R autophosphorylates