Reactome | Degradation of ubiquitinated SMAD2

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10165068
displayName	Degradation of ubiquitinated SMAD2
eventOf	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-2176452] Degradation of ubiquitinated SMAD2 - Homo sapiens
input	[Complex:R-RNO-2176443] Ub-SMAD2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Degradation of ubiquitinated SMAD2
precedingEvent	[Reaction:R-RNO-173542] SMURF2 ubiquitinates SMAD2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2176452
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling
(inferredTo)	[BlackBoxEvent:R-HSA-2176452] Degradation of ubiquitinated SMAD2

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