Reactome | SMURF2 binds SMAD2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10165066
displayName	SMURF2 binds SMAD2
eventOf	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-173542] SMURF2 ubiquitinates SMAD2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2176445] SMURF2 binds SMAD2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-3006353] SMAD2 [cytosol] [EntityWithAccessionedSequence:R-RNO-173537] Smurf2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SMURF2 binds SMAD2
output	[Complex:R-RNO-2176457] SMAD2:SMURF2 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2176445
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling
(precedingEvent)	[Reaction:R-RNO-173542] SMURF2 ubiquitinates SMAD2
(inferredTo)	[Reaction:R-HSA-2176445] SMURF2 binds SMAD2

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