Reactome | Degradation of TGF-beta receptor complex

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10164992
displayName	Degradation of TGF-beta receptor complex
eventOf	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-2169046] Degradation of TGF-beta receptor complex - Homo sapiens
input	[Complex:R-RNO-2169047] TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Degradation of TGF-beta receptor complex
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2169046
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling
(inferredTo)	[BlackBoxEvent:R-HSA-2169046] Degradation of TGF-beta receptor complex

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