Reactome | Decarboxylation of 5-hydroxytryptophan forms serotonin

Schema > Reaction > Entries

Decarboxylation of 5-hydroxytryptophan forms serotonin Show undefined attributes

catalystActivity	[CatalystActivity:10127662] aromatic-L-amino-acid decarboxylase activity of DDC dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10127664
displayName	Decarboxylation of 5-hydroxytryptophan forms serotonin
eventOf	[Pathway:R-RNO-209931] Serotonin and melatonin biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-209792] N-acetylation of serotonin - Rattus norvegicus [Reaction:R-RNO-380586] loading of Serotonin in synaptic vesicles - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-209859] Decarboxylation of 5-hydroxytryptophan forms serotonin - Homo sapiens
input	[SimpleEntity:R-ALL-209911] 5HTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Decarboxylation of 5-hydroxytryptophan forms serotonin
output	[SimpleEntity:R-ALL-209914] 5HT [cytosol] [SimpleEntity:R-ALL-113528] CO2 [cytosol]
precedingEvent	[Reaction:R-RNO-209828] Tryptophan is hydroxylated - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-209859
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-209792] N-acetylation of serotonin [Reaction:R-RNO-380586] loading of Serotonin in synaptic vesicles
(hasEvent)	[Pathway:R-RNO-209931] Serotonin and melatonin biosynthesis
(inferredTo)	[Reaction:R-HSA-209859] Decarboxylation of 5-hydroxytryptophan forms serotonin

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