Reactome | SGSH hydrolyses Heparan sulfate chain(7)

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SGSH hydrolyses Heparan sulfate chain(7) Show undefined attributes

catalystActivity	[CatalystActivity:10158120] N-sulfoglucosamine sulfohydrolase activity of SGSH:Ca2+ [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10163517
displayName	SGSH hydrolyses Heparan sulfate chain(7)
eventOf	[Pathway:R-RNO-2024096] HS-GAG degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2090085] HGSNAT oligomer acetylates Heparan chain(1) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2090043] SGSH hydrolyses Heparan sulfate chain(7) - Homo sapiens
input	[SimpleEntity:R-ALL-2090070] GlcNS3S- group [lysosomal lumen] 2 × [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	SGSH hydrolyses Heparan sulfate chain(7)
output	[SimpleEntity:R-ALL-2090045] GlcN- group [lysosomal lumen] 2 × [SimpleEntity:R-ALL-1606845] SO4(2-) [lysosomal lumen]
precedingEvent	[Reaction:R-RNO-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2090043
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-RNO-2090085] HGSNAT oligomer acetylates Heparan chain(1)
(inferredTo)	[Reaction:R-HSA-2090043] SGSH hydrolyses Heparan sulfate chain(7)

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