Reactome | CHST14 transfers SO4(2-) to GalNAc in dermatan or DS

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CHST14 transfers SO4(2-) to GalNAc in dermatan or DS Show undefined attributes

catalystActivity	[CatalystActivity:10160923] dermatan 4-sulfotransferase activity of CHST14 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10160925
displayName	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS
eventOf	[Pathway:R-RNO-2022923] DS-GAG biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2022061] Dermatan sulfate can be further sulfated on position 2 of iduronate - Rattus norvegicus [Reaction:R-RNO-9941312] CHST15 transfers sulfate to (6-)GalNAc-4-sulfate - Rattus norvegicus [BlackBoxEvent:R-RNO-2022065] DSPGs are secreted - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2022063] CHST14 transfers SO4(2-) to GalNAc in dermatan or DS - Homo sapiens
input	[DefinedSet:R-RNO-5607518] CHST14 substrates [Golgi lumen] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS GalNAc is sulfated on position 4 of GalNAc in dermatan or dermatan sulfate
output	[DefinedSet:R-RNO-5607524] CHST14 products [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-RNO-2022061] Dermatan sulfate can be further sulfated on position 2 of iduronate - Rattus norvegicus [Reaction:R-RNO-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Rattus norvegicus [Reaction:R-RNO-2022052] DSE converts GlcA to IdoA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2022063
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2022923] DS-GAG biosynthesis
(precedingEvent)	[BlackBoxEvent:R-RNO-2022065] DSPGs are secreted [Reaction:R-RNO-9941312] CHST15 transfers sulfate to (6-)GalNAc-4-sulfate [Reaction:R-RNO-2022061] Dermatan sulfate can be further sulfated on position 2 of iduronate
(inferredTo)	[Reaction:R-HSA-2022063] CHST14 transfers SO4(2-) to GalNAc in dermatan or DS

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