Reactome | Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10125638] protein tyrosine kinase activity of Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-RNO-202233] Inactivation of Lck by Csk - Rattus norvegicus [Reaction:R-RNO-202291] Activation of Lck - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10125537
displayName	Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-RNO-167542] Cd4 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-167609] LCK [cytosol] [Complex:R-RNO-203463] MHC Class II bearing antigen peptide [plasma membrane] [Complex:R-RNO-198901] T-cell receptor complex [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] - Homo sapiens
maxDepth	6
name	Antigen-bearing MHC Class II : TCR complex:CD4:Lck
producedByEvent	[Reaction:R-RNO-8852200] Inactivation of LCK by PTPN22 - Rattus norvegicus [Reaction:R-RNO-202214] Dephosphorylation of Lck-pY505 by CD45 - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-202157
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-RNO-8852200] Inactivation of LCK by PTPN22 [Reaction:R-RNO-202214] Dephosphorylation of Lck-pY505 by CD45
(input)	[Reaction:R-RNO-202291] Activation of Lck [Reaction:R-RNO-202233] Inactivation of Lck by Csk
(physicalEntity)	[CatalystActivity:10125638] protein tyrosine kinase activity of Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
(inferredTo)	[Complex:R-HSA-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]

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