Reactome | Caveolin-1 dissociates from eNOS:CaM:HSP90 complex

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Caveolin-1 dissociates from eNOS:CaM:HSP90 complex Show undefined attributes

catalystActivity	[CatalystActivity:10125377] nitric-oxide synthase regulator activity of eNOS:Caveolin-1:CaM:HSP90 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10125379
displayName	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex
eventOf	[Pathway:R-RNO-203615] eNOS activation - Rattus norvegicus [Pathway:R-RNO-5218920] VEGFR2 mediated vascular permeability - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-202137] AKT1 binds eNOS complex via HSP90 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-202144] Caveolin-1 dissociates from eNOS:CaM:HSP90 complex - Homo sapiens
input	[Complex:R-RNO-202130] eNOS:Caveolin-1:CaM:HSP90 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex
output	[EntityWithAccessionedSequence:R-RNO-163510] Cav1 [lipid droplet] [Complex:R-RNO-202105] eNOS:CaM:HSP90 [plasma membrane]
precedingEvent	[Reaction:R-RNO-202129] HSP90 binds eNOS:Caveolin-1:CaM complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-202144
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5218920] VEGFR2 mediated vascular permeability [Pathway:R-RNO-203615] eNOS activation
(precedingEvent)	[Reaction:R-RNO-202137] AKT1 binds eNOS complex via HSP90
(inferredTo)	[Reaction:R-HSA-202144] Caveolin-1 dissociates from eNOS:CaM:HSP90 complex

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