Reactome | NEDD4 binds ERBB4jmAcyt1s80 dimer

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10159680
displayName	NEDD4 binds ERBB4jmAcyt1s80 dimer
eventOf	[Pathway:R-RNO-1253288] Downregulation of ERBB4 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1973956] NEDD4 binds ERBB4jmAcyt1s80 dimer - Homo sapiens
input	[Complex:R-RNO-1252008] ERBB4jmAcyt1s80 dimer [cytosol] [EntityWithAccessionedSequence:R-RNO-975992] Nedd4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NEDD4 binds ERBB4jmAcyt1s80 dimer
output	[Complex:R-RNO-1973959] ERBB4jmAcyt1s80:NEDD4 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1973956
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-1253288] Downregulation of ERBB4 signaling
(precedingEvent)	[Reaction:R-RNO-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
(inferredTo)	[Reaction:R-HSA-1973956] NEDD4 binds ERBB4jmAcyt1s80 dimer

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