Reactome | QPRT transfers PRIB to QUIN to form NAMN

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QPRT transfers PRIB to QUIN to form NAMN Show undefined attributes

catalystActivity	[CatalystActivity:10123242] nicotinate-nucleotide diphosphorylase (carboxylating) activity of QPRT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10123244
displayName	QPRT transfers PRIB to QUIN to form NAMN
eventOf	[Pathway:R-RNO-196807] Nicotinate metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Rattus norvegicus [Reaction:R-RNO-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - Rattus norvegicus [Reaction:R-RNO-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:262876] 'de novo' NAD+ biosynthetic process from L-tryptophan
inferredFrom	[Reaction:R-HSA-197268] QPRT transfers PRIB to QUIN to form NAMN - Homo sapiens
input	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol] [SimpleEntity:R-ALL-197238] QUIN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	QPRT transfers PRIB to QUIN to form NAMN quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) => nicotinate beta-D-ribonucleotide + CO2 + diphosphate A phospho-ribosyl group is added to quinolinate
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-8869359] NAMN [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-197268
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD [Reaction:R-RNO-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD [Reaction:R-RNO-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
(hasEvent)	[Pathway:R-RNO-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-197268] QPRT transfers PRIB to QUIN to form NAMN

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