Reactome | ABCC3 transports bile salts from cytosol to extracellular region

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ABCC3 transports bile salts from cytosol to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10122762] ABC-type bile acid transporter activity of ABCC3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122764
displayName	ABCC3 transports bile salts from cytosol to extracellular region
eventOf	[Pathway:R-RNO-159418] Recycling of bile acids and salts - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-194121] SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-RNO-194079] SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol - Rattus norvegicus [Reaction:R-RNO-194083] SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol - Rattus norvegicus [Reaction:R-RNO-194130] Transport (influx) of bile salts and acids by OATP-A - Rattus norvegicus [BlackBoxEvent:R-RNO-9733545] Bile salts and acids bind ALB - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-194153] ABCC3 transports bile salts from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-ALL-194156] bile salts and acids [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCC3 transports bile salts from cytosol to extracellular region Efflux of bile salts from enterocytes to portal system by MRP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-ALL-192483] bile salts and acids [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:R-RNO-9733969] Bile salts dissociate from FABP6 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-194153
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-159418] Recycling of bile acids and salts
(precedingEvent)	[Reaction:R-RNO-194121] SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol [BlackBoxEvent:R-RNO-9733545] Bile salts and acids bind ALB [Reaction:R-RNO-194079] SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol [Reaction:R-RNO-194083] SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol [Reaction:R-RNO-194130] Transport (influx) of bile salts and acids by OATP-A
(inferredTo)	[Reaction:R-HSA-194153] ABCC3 transports bile salts from cytosol to extracellular region