Reactome | Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

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Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA Show undefined attributes

catalystActivity	[CatalystActivity:10122148] propionyl-CoA C2-trimethyltridecanoyltransferase activity of SCP2-1 [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122150
displayName	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA
eventOf	[Pathway:R-RNO-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-193385] Hydrolysis of choloyl-CoA to cholate and CoASH - Rattus norvegicus [Reaction:R-RNO-192312] Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-192341] Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA - Homo sapiens
input	[SimpleEntity:R-ALL-192339] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193514] CoA-SH [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA + CoASH => choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
output	[SimpleEntity:R-ALL-192356] choloyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-192314] propionyl CoA [peroxisomal matrix]
precedingEvent	[Reaction:R-RNO-193455] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-192341
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[Reaction:R-RNO-193385] Hydrolysis of choloyl-CoA to cholate and CoASH [Reaction:R-RNO-192312] Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate
(inferredTo)	[Reaction:R-HSA-192341] Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

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