Reactome | CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol

Schema > Reaction > Entries

CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol Show undefined attributes

catalystActivity	[CatalystActivity:10122001] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122003
displayName	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol
eventOf	[Pathway:R-RNO-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-191999] CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol - Homo sapiens
input	[SimpleEntity:R-ALL-192078] 5bCHOL3a,7a,12a-triol [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol + NADP+ + H2O
output	[SimpleEntity:R-ALL-192201] 5bCHOL3a,7a,12a,27-tetrol [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-191999
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[Reaction:R-RNO-192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
(inferredTo)	[Reaction:R-HSA-191999] CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol

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