Reactome | Rab5-mediated recruitment of class III PI3K to TLR9

Schema > Reaction > Entries

Rab5-mediated recruitment of class III PI3K to TLR9 Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10120988
displayName	Rab5-mediated recruitment of class III PI3K to TLR9
eventOf	[Pathway:R-RNO-168138] Toll Like Receptor 9 (TLR9) Cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-188002] Rab5-mediated recruitment of class III PI3K to TLR9 - Homo sapiens
input	[Complex:R-RNO-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] [Complex:R-RNO-188015] PI3K class III [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Rab5-mediated recruitment of class III PI3K to TLR9
output	[Complex:R-RNO-188017] activated TLR9:PI3K class III [cytosol]
precedingEvent	[Reaction:R-RNO-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Rattus norvegicus
regulatedBy	[Requirement:10120989] Requirement by 'ZFYVE20 [endosome membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-188002
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-168138] Toll Like Receptor 9 (TLR9) Cascade
(precedingEvent)	[Reaction:R-RNO-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-188002] Rab5-mediated recruitment of class III PI3K to TLR9

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