Reactome | EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10120410] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10120379
displayName	EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
hasComponent	[Complex:R-RNO-180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] [Complex:R-RNO-109797] GRB2-1:SOS1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens
maxDepth	5
memberOf	[DefinedSet:R-RNO-5672601] RAS GEFs [plasma membrane] - Rattus norvegicus
name	EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1
producedByEvent	[Reaction:R-RNO-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-180331
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(physicalEntity)	[CatalystActivity:10120410] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
(output)	[Reaction:R-RNO-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
(hasMember)	[DefinedSet:R-RNO-5672601] RAS GEFs [plasma membrane]
(inferredTo)	[Complex:R-HSA-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]

Cite Us!