Reactome | ATR:ATRIP [nucleoplasm]

Schema > Complex > Entries

ATR:ATRIP [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10119839] protein serine/threonine kinase activity of ATR:ATRIP [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-9980013] ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex - Rattus norvegicus [Reaction:R-RNO-5684875] Binding of ATR:ATRIP to RPA at resected DNA DSBs - Rattus norvegicus [Reaction:R-RNO-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10119838
displayName	ATR:ATRIP [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-RNO-912443] Atr [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-176231] Atrip [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-176269] ATR:ATRIP [nucleoplasm] - Homo sapiens
maxDepth	2
name	ATR:ATRIP
producedByEvent	[BlackBoxEvent:R-RNO-5686663] Completion of SSA - Rattus norvegicus [Reaction:R-RNO-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-176269
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-RNO-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA [BlackBoxEvent:R-RNO-5686663] Completion of SSA
(input)	[Reaction:R-RNO-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA [Reaction:R-RNO-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex [Reaction:R-RNO-5684875] Binding of ATR:ATRIP to RPA at resected DNA DSBs
(hasComponent)	[Complex:R-RNO-6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] [Complex:R-RNO-176281] ATR:ATRIP:RPA:ssDNA signaling complex [nucleoplasm] [Complex:R-RNO-9980013] ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Complex:R-RNO-5686619] ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Complex:R-RNO-5685178] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Complex:R-RNO-5684874] ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(physicalEntity)	[CatalystActivity:10119839] protein serine/threonine kinase activity of ATR:ATRIP [nucleoplasm]
(activeUnit)	[CatalystActivity:10183857] protein serine/threonine kinase activity of ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] [CatalystActivity:10183864] protein serine/threonine kinase activity of ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(inferredTo)	[Complex:R-HSA-176269] ATR:ATRIP [nucleoplasm]

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