Reactome | Recruitment of DNA2 endonuclease to the C strand

Schema > Reaction > Entries

Recruitment of DNA2 endonuclease to the C strand Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10119350
displayName	Recruitment of DNA2 endonuclease to the C strand
eventOf	[Pathway:R-RNO-174437] Removal of the Flap Intermediate from the C-strand - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
inferredFrom	[Reaction:R-HSA-174451] Recruitment of DNA2 endonuclease to the C strand - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-68465] DNA2 [nucleoplasm] [Complex:R-RNO-174436] Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment of DNA2 endonuclease to the C strand
output	[Complex:R-RNO-174442] Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-174445] RPA binds to the Flap on the C-strand - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-174451
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-174437] Removal of the Flap Intermediate from the C-strand
(precedingEvent)	[Reaction:R-RNO-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
(inferredTo)	[Reaction:R-HSA-174451] Recruitment of DNA2 endonuclease to the C strand

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