Reactome | Spontaneous hydrolysis of C3 thioester

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10118953
displayName	Spontaneous hydrolysis of C3 thioester
eventOf	[Pathway:R-RNO-173736] Alternative complement activation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-173739] Spontaneous hydrolysis of C3 thioester - Homo sapiens
input	[Complex:R-RNO-166822] Complement factor 3 [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Spontaneous hydrolysis of C3 thioester
output	[Complex:R-RNO-182450] C3(H2O) [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-173739
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-173736] Alternative complement activation
(inferredTo)	[Reaction:R-HSA-173739] Spontaneous hydrolysis of C3 thioester

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