Reactome | I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)

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I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) Show undefined attributes

category	binding
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10118226
displayName	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
eventOf	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23765] negative regulation of transforming growth factor beta receptor signaling pathway
inferredFrom	[Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-173478] SMAD7 [cytosol] [Complex:R-RNO-170841] TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
output	[Complex:R-RNO-173476] TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-173512
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2173788] Downregulation of TGF-beta receptor signaling
(inferredTo)	[Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)

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