Reactome | ARMS-mediated activation

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222889
displayName	ARMS-mediated activation
eventOf	[Pathway:R-RNO-169893] Prolonged ERK activation events - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-169905] ARMS is phosphorylated by active TrkA receptor - Rattus norvegicus [Reaction:R-RNO-169895] Crk's SH3 domain engages C3G - Rattus norvegicus [Reaction:R-RNO-169904] C3G stimulates nucleotide exchange on Rap1 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-170984] ARMS-mediated activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	ARMS-mediated activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-170984
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-169893] Prolonged ERK activation events
(inferredTo)	[Pathway:R-HSA-170984] ARMS-mediated activation

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