Reactome | Adenylate cyclase inhibitory pathway

Schema > Pathway > Entries

Adenylate cyclase inhibitory pathway Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222899
displayName	Adenylate cyclase inhibitory pathway
eventOf	[Pathway:R-RNO-991365] Activation of GABAB receptors - Rattus norvegicus [Pathway:R-RNO-112040] G-protein mediated events - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19330] adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-170671] G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex - Rattus norvegicus [Reaction:R-RNO-170666] Adenylate cyclase increases the GTPase activity of G alpha-olf - Rattus norvegicus [Reaction:R-RNO-170686] Adenylate cyclase increases the GTPase activity of Gi alpha - Rattus norvegicus [Reaction:R-RNO-170674] Dissociation of the Gi alpha:G olf complex - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-170670] Adenylate cyclase inhibitory pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Adenylate cyclase inhibitory pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-170670
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-991365] Activation of GABAB receptors [Pathway:R-RNO-112040] G-protein mediated events
(inferredTo)	[Pathway:R-HSA-170670] Adenylate cyclase inhibitory pathway