Reactome | Secreted CD14 binds LPS

Schema > Reaction > Entries

Secreted CD14 binds LPS Show undefined attributes

category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10117557
displayName	Secreted CD14 binds LPS
eventOf	[Pathway:R-RNO-166020] Transfer of LPS from LBP carrier to CD14 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-166041] Transfer of LPS onto TLR4 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-169719] Secreted CD14 binds LPS - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-166025] Cd14 [extracellular region] [Complex:R-RNO-166013] LBP:bacterial LPS [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Secreted CD14 binds LPS
output	[EntityWithAccessionedSequence:R-RNO-166010] Lbp [extracellular region] [Complex:R-RNO-166026] LPS:secreted CD14 [extracellular region]
precedingEvent	[Reaction:R-RNO-166015] Association of LBP with LPS - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-169719
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-166020] Transfer of LPS from LBP carrier to CD14
(precedingEvent)	[Reaction:R-RNO-166041] Transfer of LPS onto TLR4
(inferredTo)	[Reaction:R-HSA-169719] Secreted CD14 binds LPS