Reactome | PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane

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PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane Show undefined attributes

catalystActivity	[CatalystActivity:10157755] 1-phosphatidylinositol 4-kinase activity of PI4K2A/2B [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10157884
displayName	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
eventOf	[Pathway:R-RNO-1660516] Synthesis of PIPs at the early endosome membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1675974] PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1806199] PI [early endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1806180] PI4P [early endosome membrane]
precedingEvent	[Reaction:R-RNO-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1675974
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1660516] Synthesis of PIPs at the early endosome membrane
(inferredTo)	[Reaction:R-HSA-1675974] PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
(precedingEvent)	[Reaction:R-RNO-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

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