Reactome | PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

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PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane Show undefined attributes

catalystActivity	[CatalystActivity:10157806] phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of OCRL/INPP5E [cytosol]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10157808
displayName	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
eventOf	[Pathway:R-RNO-1660514] Synthesis of PIPs at the Golgi membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane - Rattus norvegicus [Reaction:R-RNO-1676133] PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1675824] PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806165] PI(4,5)P2 [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806217] PI4P [Golgi membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1675824
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1660514] Synthesis of PIPs at the Golgi membrane
(precedingEvent)	[Reaction:R-RNO-1675928] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane [Reaction:R-RNO-1676133] PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
(inferredTo)	[Reaction:R-HSA-1675824] PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

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