Reactome | PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane

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PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10157755] 1-phosphatidylinositol 4-kinase activity of PI4K2A/2B [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10157757
displayName	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
eventOf	[Pathway:R-RNO-1660499] Synthesis of PIPs at the plasma membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane - Rattus norvegicus [Reaction:R-RNO-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Rattus norvegicus [Reaction:R-RNO-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1675780] PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-426658] PI [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
precedingEvent	[Reaction:R-RNO-1675994] PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane - Rattus norvegicus [Reaction:R-RNO-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1675780
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1660499] Synthesis of PIPs at the plasma membrane
(precedingEvent)	[Reaction:R-RNO-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane [Reaction:R-RNO-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Reaction:R-RNO-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
(inferredTo)	[Reaction:R-HSA-1675780] PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane