Reactome | GTP loading by Rheb

Schema > Reaction > Entries

GTP loading by Rheb Show undefined attributes

category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10116589
displayName	GTP loading by Rheb
eventOf	[Pathway:R-RNO-165159] MTOR signalling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-165680] Formation of active mTORC1 complex - Rattus norvegicus [Reaction:R-RNO-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-165195] GTP loading by Rheb - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-RNO-165191] RHEB:GDP [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GTP loading by Rheb
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-RNO-165189] RHEB:GTP [lysosomal membrane]
precedingEvent	[Reaction:R-RNO-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-165195
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-165159] MTOR signalling
(precedingEvent)	[Reaction:R-RNO-165680] Formation of active mTORC1 complex [Reaction:R-RNO-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP
(inferredTo)	[Reaction:R-HSA-165195] GTP loading by Rheb