Reactome | SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases

Schema > Reaction > Entries

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases Show undefined attributes

catalystActivity	[CatalystActivity:10157173] oxidoreductase activity of SUMF1 [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10157175
displayName	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
eventOf	[Pathway:R-RNO-1663150] The activation of arylsulfatases - Rattus norvegicus [Pathway:R-RNO-9840310] Glycosphingolipid catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2248891] M6PR transports activated ARSA to the lysosome - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1614362] SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases - Homo sapiens
input	[DefinedSet:R-RNO-1614312] ARS [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-194653] NAD+ [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
output	[DefinedSet:R-RNO-1614309] active ARS [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-1663154] H2S [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-194697] NADH [endoplasmic reticulum lumen]
regulatedBy	[NegativeRegulation:10157176] Negative regulation by 'SUMF1:SUMF2 [endoplasmic reticulum lumen]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1614362
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1663150] The activation of arylsulfatases [Pathway:R-RNO-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-RNO-2248891] M6PR transports activated ARSA to the lysosome
(inferredTo)	[Reaction:R-HSA-1614362] SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases

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