Reactome | factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)

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factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10114786] serine-type endopeptidase activity of factor XIIa [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10114788
displayName	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
eventOf	[Pathway:R-RNO-9935598] FXIIa, PKa-dependent activation of coagulation pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9657706] factor XIa binds APP(18-770) - Rattus norvegicus [Reaction:R-RNO-9655851] factor XIa binds SERPINE1 - Rattus norvegicus [Reaction:R-RNO-9653838] factor XIa binds SERPING1 - Rattus norvegicus [Reaction:R-RNO-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) - Rattus norvegicus [Reaction:R-RNO-9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Homo sapiens
input	[Complex:R-RNO-158162] factor XI:GPIb-IX-V complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
output	[Complex:R-RNO-158130] factor XIa:GPIb:GPIX:GPV complex [plasma membrane]
precedingEvent	[Reaction:R-RNO-158313] factor XII -> factor XIIa - Rattus norvegicus [Reaction:R-RNO-158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - Rattus norvegicus [Reaction:R-RNO-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Rattus norvegicus [Reaction:R-RNO-9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) - Rattus norvegicus [Reaction:R-RNO-9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-158300
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9935598] FXIIa, PKa-dependent activation of coagulation pathway
(precedingEvent)	[Reaction:R-RNO-9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) [Reaction:R-RNO-9657706] factor XIa binds APP(18-770) [Reaction:R-RNO-9655851] factor XIa binds SERPINE1 [Reaction:R-RNO-9653838] factor XIa binds SERPING1 [Reaction:R-RNO-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
(inferredTo)	[Reaction:R-HSA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)