Reactome | Collagen type VIII degradation by MMP1

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Collagen type VIII degradation by MMP1 Show undefined attributes

catalystActivity	[CatalystActivity:10156338] metalloendopeptidase activity of MMP1(100-469) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10156340
displayName	Collagen type VIII degradation by MMP1
eventOf	[Pathway:R-RNO-1442490] Collagen degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1564169] Collagen type VIII degradation by MMP1 - Homo sapiens
input	[Polymer:R-RNO-2168017] Collagen type VIII fibril [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Collagen type VIII degradation by MMP1
output	[Polymer:R-RNO-2470314] Cleaved collagen type VIII fibril [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1564169
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1442490] Collagen degradation
(precedingEvent)	[BlackBoxEvent:R-RNO-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
(inferredTo)	[Reaction:R-HSA-1564169] Collagen type VIII degradation by MMP1

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