Reactome | Amplification of signal from the kinetochores

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Amplification of signal from the kinetochores Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222631
displayName	Amplification of signal from the kinetochores
eventOf	[Pathway:R-RNO-69618] Mitotic Spindle Checkpoint - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-RNO-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components - Rattus norvegicus
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-RNO-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-141424] Amplification of signal from the kinetochores - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Amplification of signal from the kinetochores
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-141424
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-69618] Mitotic Spindle Checkpoint
(precedingEvent)	[Pathway:R-RNO-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
(inferredTo)	[Pathway:R-HSA-141424] Amplification of signal from the kinetochores

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