Reactome | Presynaptic depolarization and calcium channel opening

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Presynaptic depolarization and calcium channel opening Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223411
displayName	Presynaptic depolarization and calcium channel opening
eventOf	[Pathway:R-RNO-112315] Transmission across Chemical Synapses - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-RNO-112310] Neurotransmitter release cycle - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:262351] membrane depolarization
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-210420] Ca2+ influx through voltage gated Ca2+ channels - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-112308] Presynaptic depolarization and calcium channel opening - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Presynaptic depolarization and calcium channel opening
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-112308
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-112315] Transmission across Chemical Synapses
(precedingEvent)	[Pathway:R-RNO-112310] Neurotransmitter release cycle
(inferredTo)	[Pathway:R-HSA-112308] Presynaptic depolarization and calcium channel opening

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