Reactome | Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151017
displayName	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-RNO-873794] Socs3 [cytosol] [Complex:R-RNO-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1112718] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] - Homo sapiens
maxDepth	7
name	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3
negativelyRegulates	[NegativeRegulation:10151020] Negative regulation by 'Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane]'
producedByEvent	[Reaction:R-RNO-1112755] SOCS3 binds IL6ST - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1112718
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-RNO-1112755] SOCS3 binds IL6ST
(regulator)	[NegativeRegulation:10151020] Negative regulation by 'Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane]'
(inferredTo)	[Complex:R-HSA-1112718] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane]

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