Reactome | Activated JAK1, JAK2, TYK2 [cytosol]

Schema > CandidateSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-1112556] IL6RB:Activated JAKs [plasma membrane] - Rattus norvegicus [Complex:R-RNO-1112563] Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10111395
displayName	Activated JAK1, JAK2, TYK2 [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-RNO-1112598] phospho-p-Y1054-TYK2 [cytosol] - Rattus norvegicus
hasMember	[EntityWithAccessionedSequence:R-RNO-1112543] phospho-p-Y1034-JAK1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-1168862] p-Y1007-Jak2 [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[CandidateSet:R-HSA-1112596] Activated JAK1, JAK2, TYK2 [cytosol] - Homo sapiens
maxDepth	2
name	Activated JAK1, JAK2, TYK2
schemaClass	CandidateSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1112596

(activeUnit)	[CatalystActivity:10151060] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] [CatalystActivity:10151015] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] [CatalystActivity:10221636] protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane]
(hasComponent)	[Complex:R-RNO-1112556] IL6RB:Activated JAKs [plasma membrane] [Complex:R-RNO-1112563] Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]
(inferredTo)	[CandidateSet:R-HSA-1112596] Activated JAK1, JAK2, TYK2 [cytosol]