Reactome | LIG1 binds APEX1 and PCNA at SSB

Schema > Reaction > Entries

LIG1 binds APEX1 and PCNA at SSB Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10111856
displayName	LIG1 binds APEX1 and PCNA at SSB
eventOf	[Pathway:R-RNO-5651801] PCNA-Dependent Long Patch Base Excision Repair - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5651805] LIG1 bound to APEX1 and PCNA ligates SSB - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-110371] LIG1 binds APEX1 and PCNA at SSB - Homo sapiens
input	[Complex:R-RNO-5651804] APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-53787] LIG1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	LIG1 binds APEX1 and PCNA at SSB Interaction of APE1 with DNA ligase I
output	[Complex:R-RNO-5651808] LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-110371
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5651801] PCNA-Dependent Long Patch Base Excision Repair
(precedingEvent)	[Reaction:R-RNO-5651805] LIG1 bound to APEX1 and PCNA ligates SSB
(inferredTo)	[Reaction:R-HSA-110371] LIG1 binds APEX1 and PCNA at SSB

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