Reactome | Insertion of correct bases opposite the lesion by POLH

Schema > Reaction > Entries

Insertion of correct bases opposite the lesion by POLH Show undefined attributes

catalystActivity	[CatalystActivity:10111782] DNA-directed DNA polymerase activity of POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10111784
displayName	Insertion of correct bases opposite the lesion by POLH
eventOf	[Pathway:R-RNO-110320] Translesion Synthesis by POLH - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-110319] Elongation by POLH - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-110317] Insertion of correct bases opposite the lesion by POLH - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29604] dATP [nucleoplasm] [Complex:R-RNO-110288] POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Insertion of correct bases opposite the lesion by POLH
output	[Complex:R-RNO-110290] POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] 2 × [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-RNO-110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-110317
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-110320] Translesion Synthesis by POLH
(precedingEvent)	[Reaction:R-RNO-110319] Elongation by POLH
(inferredTo)	[Reaction:R-HSA-110317] Insertion of correct bases opposite the lesion by POLH

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