Reactome | MAP2K2 binds MAPK1

Schema > Reaction > Entries

MAP2K2 binds MAPK1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10111424
displayName	MAP2K2 binds MAPK1
eventOf	[Pathway:R-RNO-112411] MAPK1 (ERK2) activation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-109862] MAP2K2 phosphorylates MAPK1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-109858] MAP2K2 binds MAPK1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-59282] MAPK1 [cytosol] [EntityWithAccessionedSequence:R-RNO-109848] phospho-p-S,T-MAP2K2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAP2K2 binds MAPK1
output	[Complex:R-RNO-109849] p-S,T-MAP2K2:MAPK1 [cytosol]
regulatedBy	[PositiveRegulation:10111414] Positive regulation by 'IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-109858
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-112411] MAPK1 (ERK2) activation
(precedingEvent)	[Reaction:R-RNO-109862] MAP2K2 phosphorylates MAPK1
(inferredTo)	[Reaction:R-HSA-109858] MAP2K2 binds MAPK1