Reactome | CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

Schema > Reaction > Entries

CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] Show undefined attributes

catalystActivity	[CatalystActivity:10110805] 5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10110809
displayName	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
eventOf	[Pathway:R-RNO-73621] Pyrimidine catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-109291] CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] - Homo sapiens
input	[DefinedSet:R-ALL-500316] CMP, TMP, UMP [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] CMP + H2O => cytidine + phosphate dTMP + H2O => thymidine + phosphate UMP + H2O => uridine + phosphate
output	[DefinedSet:R-ALL-500318] Cyt-Rib, Thy-dRib, Ura-Rib [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-109291
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-73621] Pyrimidine catabolism
(inferredTo)	[Reaction:R-HSA-109291] CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

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