Reactome | GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE

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GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE Show undefined attributes

catalystActivity	[CatalystActivity:11125560] phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11125564
displayName	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE
eventOf	[Pathway:R-PFA-9023661] Biosynthesis of E-series 18(R)-resolvins - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9018895] GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE - Homo sapiens
input	[SimpleEntity:R-ALL-9023653] 18(R)-HpEPE [cytosol] 2 × [SimpleEntity:R-ALL-29450] GSH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE
output	[SimpleEntity:R-ALL-9023651] 18(R)-HEPE [cytosol] [SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-9018895
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-9023661] Biosynthesis of E-series 18(R)-resolvins
(inferredTo)	[Reaction:R-HSA-9018895] GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE

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