Reactome | hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate

Schema > Reaction > Entries

hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate Show undefined attributes

catalystActivity	[CatalystActivity:11110621] dUTP diphosphatase activity of DUT trimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11110623
displayName	hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate
eventOf	[Pathway:R-PFA-499943] Interconversion of nucleotide di- and triphosphates - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-73605] conversion of dUMP to dTMP - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-73666] hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-500739] dUTP [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate dUTP + H2O => dUMP + diphosphate + H(+) dUTP + H2O => dUMP + pyrophosphate
output	[SimpleEntity:R-ALL-500742] dUMP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-73666
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-PFA-73605] conversion of dUMP to dTMP
(inferredTo)	[Reaction:R-HSA-73666] hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate

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