Reactome | Co-inhibition by PD-1

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11129326
displayName	Co-inhibition by PD-1
eventOf	[Pathway:R-PFA-388841] Regulation of T cell activation by CD28 family - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-PFA-9909648] Regulation of PD-L1(CD274) expression - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-389948] Co-inhibition by PD-1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	Co-inhibition by PD-1 PD-1 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-389948
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-PFA-388841] Regulation of T cell activation by CD28 family
(inferredTo)	[Pathway:R-HSA-389948] Co-inhibition by PD-1
(hasEncapsulatedEvent)	[Pathway:R-PFA-9909615] Regulation of PD-L1(CD274) Post-translational modification

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