Reactome | Formation of Malonyl-CoA from Acetyl-CoA (liver)

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Formation of Malonyl-CoA from Acetyl-CoA (liver) Show undefined attributes

catalystActivity	[CatalystActivity:11112656] acetyl-CoA carboxylase activity of Btn-ACACA [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11112658
displayName	Formation of Malonyl-CoA from Acetyl-CoA (liver)
eventOf	[Pathway:R-PFA-75105] Fatty acyl-CoA biosynthesis - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-111627] HCO3- [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of Malonyl-CoA from Acetyl-CoA (liver) acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29508] Mal-CoA [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[PositiveRegulation:R-HSA-8876882] Positive regulation by 'CIT [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-200555
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-75105] Fatty acyl-CoA biosynthesis
(inferredTo)	[Reaction:R-HSA-200555] Formation of Malonyl-CoA from Acetyl-CoA (liver)

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