Reactome | FECH binds Fe2+ to PRIN9 to form heme

Schema > Reaction > Entries

FECH binds Fe2+ to PRIN9 to form heme Show undefined attributes

catalystActivity	[CatalystActivity:11112349] ferrochelatase activity of 2x(FECH:2Fe-2S cluster) [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11112351
displayName	FECH binds Fe2+ to PRIN9 to form heme
eventOf	[Pathway:R-PFA-189451] Heme biosynthesis - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-2995330] COX10 transforms heme to heme O - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-189465] FECH binds Fe2+ to PRIN9 to form heme - Homo sapiens
input	[SimpleEntity:R-ALL-113531] Fe2+ [mitochondrial matrix] [SimpleEntity:R-ALL-189487] PRIN9 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	FECH binds Fe2+ to PRIN9 to form heme Fe(2+) + protoporphyrin IX => 2 H(+) + heme b Ferrous iron is inserted into protoporphyrin IX to form heme
output	2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-9853511] heme b [mitochondrial inner membrane]
regulatedBy	[NegativeRegulation:R-HSA-190303] Negative regulation by 'Pb2+ [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-189465
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-PFA-2995330] COX10 transforms heme to heme O
(inferredTo)	[Reaction:R-HSA-189465] FECH binds Fe2+ to PRIN9 to form heme

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