Reactome | Macroautophagy

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Macroautophagy Show undefined attributes

created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11129020
displayName	Macroautophagy
eventOf	[TopLevelPathway:R-PFA-9612973] Autophagy - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20607] macroautophagy
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-PFA-5681980] ATG12 binds ATG7 dimer - Plasmodium falciparum [Reaction:R-PFA-9020616] ATG12 forms a thioester bond with ATG7 dimer - Plasmodium falciparum [Reaction:R-PFA-5681987] LC3 is cleaved by ATG4 - Plasmodium falciparum [BlackBoxEvent:R-PFA-5682011] LC3 binds ATG7 dimer - Plasmodium falciparum [Reaction:R-PFA-5682896] LC3:ATG7 dimer binds ATG3 - Plasmodium falciparum [Reaction:R-PFA-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Plasmodium falciparum [Reaction:R-PFA-5683593] ATG7:ATG3:LC3 dissociates - Plasmodium falciparum [Reaction:R-PFA-5682377] LC3 de-lipidation by ATG4 - Plasmodium falciparum [BlackBoxEvent:R-PFA-5682388] Autophagosome maturation - Plasmodium falciparum [Pathway:R-PFA-9663891] Selective autophagy - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-1632852] Macroautophagy - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Macroautophagy
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-1632852
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-PFA-9612973] Autophagy
(inferredTo)	[Pathway:R-HSA-1632852] Macroautophagy

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