Reactome | Cleavage of 5-hydroxyluracil by UNG glycosylase

Schema > Reaction > Entries

Cleavage of 5-hydroxyluracil by UNG glycosylase Show undefined attributes

catalystActivity	[CatalystActivity:11111195] uracil DNA N-glycosylase activity of UNG-1:5-OHU-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11111197
displayName	Cleavage of 5-hydroxyluracil by UNG glycosylase
eventOf	[Pathway:R-PFA-110329] Cleavage of the damaged pyrimidine - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-110217] Cleavage of 5-hydroxyluracil by UNG glycosylase - Homo sapiens
input	[Complex:R-PFA-110154] UNG-1:5-OHU-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of 5-hydroxyluracil by UNG glycosylase
output	[SimpleEntity:R-ALL-110216] 5-OHU [nucleoplasm] [Complex:R-PFA-110188] UNG-1:AP-dsDNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-110217
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-PFA-110349] Displacement of UNG glycosylase by APEX1 at the AP site
(hasEvent)	[Pathway:R-PFA-110329] Cleavage of the damaged pyrimidine
(inferredTo)	[Reaction:R-HSA-110217] Cleavage of 5-hydroxyluracil by UNG glycosylase

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