Reactome | Mutyh G257E,Mutyh A341V:(OGUA:Ade)-dsDNA [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[FailedReaction:R-NUL-9606338] Defective Mutyh mutants do not cleave adenine mispaired with 8-oxoguanine - Mus musculus
created	[InstanceEdit:9606339] Orlic-Milacic, Marija, 2018-04-20
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9606341
disease	[Disease:1500689] cancer
displayName	Mutyh G257E,Mutyh A341V:(OGUA:Ade)-dsDNA [nucleoplasm]
hasComponent	[GenomeEncodedEntity:R-HSA-110198] (8oxoG:Ade)-dsDNA [nucleoplasm] [DefinedSet:R-MMU-9606336] Mutyh G257E,Mutyh A341V [nucleoplasm]
inDisease	true
isChimeric	true
literatureReference	[LiteratureReference:9606302] Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis
maxDepth	3
modified	[InstanceEdit:9616932] Orlic-Milacic, Marija, 2018-08-15
name	Mutyh G257E,Mutyh A341V:(OGUA:Ade)-dsDNA
schemaClass	Complex
species	[Species:48892] Mus musculus [Species:48887] Homo sapiens
stId	R-NUL-9606341

(input)	[FailedReaction:R-NUL-9606338] Defective Mutyh mutants do not cleave adenine mispaired with 8-oxoguanine
(diseaseEntity)	[EntityFunctionalStatus:9606342] loss_of_function of Mutyh G257E,Mutyh A341V:(OGUA:Ade)-dsDNA [nucleoplasm]

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