Reactome | Ntrk2 activates Ras signaling through Frs2

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Ntrk2 activates Ras signaling through Frs2 Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9032388] guanyl-nucleotide exchange factor activity of BDNF:p-5Y-Ntrk2 homodimer:p-Y-Frs2:Grb2:Sos1 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9032384] Orlic-Milacic, Marija, 2017-12-12
dbId	9032387
displayName	Ntrk2 activates Ras signaling through Frs2
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-RNO-112372] p21 Ras:GDP [plasma membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9031570] Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2 [LiteratureReference:9031991] The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ntrk2 activates Ras signaling through Frs2
orthologousEvent	[BlackBoxEvent:R-HSA-9032067] NTRK2 activates RAS signaling through FRS2 - Homo sapiens
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-RNO-112373] p21 Ras:GTP [plasma membrane]
regulatedBy	[PositiveRegulation:R-NUL-9032385] Positive regulation by 'BDNF:p-5Y-Ntrk2 homodimer:p-Y-Frs2:Ptpn11 [plasma membrane]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens [Species:48895] Rattus norvegicus
stId	R-NUL-9032387
summation	[Summation:9032393] In rat cells, Frs2 is involved in TrkB (Ntrk2)-mediated acti...

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