Reactome | NTF4-bound Ntrk2 dimers trans-autophosphorylate

Schema > Reaction > Entries

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9030428] protein tyrosine kinase activity of NTF4:Ntrk2 homodimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9030426] Orlic-Milacic, Marija, 2017-11-27
dbId	9030427
displayName	NTF4-bound Ntrk2 dimers trans-autophosphorylate
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-NUL-9030416] NTF4:Ntrk2 homodimer [plasma membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9026486] Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTF4-bound Ntrk2 dimers trans-autophosphorylate
orthologousEvent	[Reaction:R-HSA-9026510] NTF4-bound NTRK2 dimers trans-autophosphorylate - Homo sapiens
output	10 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-NUL-9030413] NTF4:p-5Y-Ntrk2 homodimer [plasma membrane]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus
stId	R-NUL-9030427
summation	[Summation:9030425] A recombinant human NTF4 (NT-4) induces trans-autophosphoryl...

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